In the current study, the proteome analysis of the FOXO3a, Atrogin-1, and MuRF1 levels in ALS mice revealed a significant shift in the expression of these proteins in the TERMINAL trained group towards the BEFORE group levels, which further confirms the effectiveness of swim training as an anti-atrophic agent. The gene discussed is FBXO32; the disease is amyotrophic lateral sclerosis.