Four major quantitative trait loci (QTLs): the beta globin gene (HBB) locus, the B-cell lymphoma/leukemia 11A (BCL11A)gene, the HBS1 Like Translational GTPase-MYB Proto-Oncogene (HBSB1L-cMYB) inter-region along with Krueppel-like factor 1 (KLF1) gene variations bring about 20–50% variation in HbF levels in hemoglobinopathy patients5. Here, HBB is linked to hemoglobinopathy.