Cardoso et al.43, studied the influence of three known major loci on the HbF trait (HBG2, rs748214; BCL11A, rs4671393; and HBS1L-MYB, rs28384513, rs489544 and rs9399137) in north Brazilian SCA patients and they showed that the raised HbF trait was primarily influenced by mutant alleles of BCL11A43. This evidence concerns the gene MYB and autosomal dominant cerebellar ataxia.