HIF1A and malignant colon neoplasm: The combination of TAS-116 and palbociclib or abemaciclib markedly reduced the level of HIF1α (Supplementary Fig. S4A, D) and synergistically suppressed cell viability in SW480 colon cancer cells both in normoxia (Supplementary Fig. S4B, E) and hypoxia (Supplementary Fig. S4C, F).