SOAT1 and autosomal recessive polycystic kidney disease: Of the 15 cell clusters, cluster 0 was of particular interest because: (i) it had the largest increase in ARPKD (27%) versus control (2.9%) organoids, and (ii) pathway enrichment analysis indicated that they expressed mRNAs associated with protein digestion, the JAK-STAT pathway, and ECM-receptor interactions (Fig. 5a–c).