PIAS2 and gastric neoplasm: Clinically, the GEPIA database (http://gepia.cancer-pku.cn) showed that the expression of PIASx (including PIASxα and PIASxβ) was significantly higher in gastric tumor samples than in normal tissues (Fig. 6i), and this finding was confirmed at the protein level, together with the activities of p38α and MK2, using fresh surgical specimens from patients (Fig. 6j).