CD274 and myocarditis: Interestingly, cardiomyocyte PD-L1 expression is upregulated in cardiac injury and inflammation, suggesting that PD-L1 signaling might have a cardioprotective immunomodulatory effect.7 Early detection, timely intervention, and the initiation of adequate immunosuppressive (IS) treatment, can reduce mortality and improve the prognosis of ICI-related myocarditis.