In the presence of 2 mM GuHCl, RV-B14 and RV-A16 infection in ICAM-1−/− cells resulted in little viral loads in cell lysates at all time points (Fig. 4c, d), which was in consistency with the above results of ICAM-1−/− cells (Fig. 3a, b). The gene discussed is ICAM1; the disease is infection.