Among tumor-derived angiogenic factors and cytokines, vascular endothelial growth factor A (VEGF-A, also called VEGF) is the major mediator of tumor angiogenesis, specifically the two circulating isoforms-VEGF121 and VEGF165 signaling through VEGF receptor 2 (VEGFR-2) [1, 4–6]. The gene discussed is KDR; the disease is neoplasm.