In testing the inhibition of enzymes (acetylcholinesterase, butyrylcholinesterase, and tyrosinase) involved in neurodegenerative diseases, it was shown that except for proline-lactic acid against butyrylcholinesterase, all organic-acid-based NADES extracts (with strong acid pH) showed the greatest potential to inhibit acetylcholinesterase and butyrylcholinesterase. Here, ACHE is linked to neurodegenerative disease.