In addition to neutropenia, patients with concomitant LGLL and MDS generally display anemia and/or thrombocytopenia, typical MDS-related features, such as myeloid dysplasia, cytogenetic abnormalities, increase in blasts count and the presence of clonal myeloid mutations (e.g., TET2, DNMT3A, SF3B1, ASXL1) [71,72]. The gene discussed is SF3B1; the disease is myelodysplastic syndrome.