Since MMP7 was shown (i) to have a detrimental role in cardiac remodelling post myocardial infarction (MI) and (ii) to promote the development of renal fibrosis in experimental mouse models [46,47], it remains to be seen whether the spironolactone-induced increase in MMP7 expression may also cause damage in the HFpEF setting. Here, MMP7 is linked to renal fibrosis.