CCL17 and hydrops fetalis: In this regard, our data suggest that beneficial effects through spironolactone may depend on levels of distinct inflammatory cytokines (e.g., interleukins and related peptides such as IL4RA, IL1ra, IL16 and IL18) and chemokines (e.g., CCL17, CCL3), a group of molecules known to be involved in HF development [53].