RRAD and hyperinsulinemic hypoglycemia, familial, 4: Generating a human embryonic stem cell line (hESCs) with RAD deficiency (RRAD−/−) through CRISPR/Cas9 technique, Li et al. observed that RAD absence was responsible for the onset of a HCM phenotype development, with the RAD hESCs line displaying typical phenotypical features of HCM, e.g., increased size of cardiomyocytes, multi-nucleation and impairment of Ca2+ transient.