This is the first study proving the development of hepatocellular adenomas and carcinomas from glycogen-storing clear cell foci (CCF) in diabetic mice, both in wild type (WT) and ChREBP-knockout (KO) mice due to insulin-mediated metabolic and molecular alterations in hepatocytes after intraportal pancreatic islet transplantation. This evidence concerns the gene MLXIPL and carcinoma.