Gene Pfkfb4, with 1.7 fold upregulation in WT tumor, encodes the tissue specific 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 enzyme and is considered to be activator of the key regulatory enzyme of the glycolysis, fructose 2,6-bisphosphate (F2,6BP) [25,26]. The gene discussed is PFKFB4; the disease is neoplasm.