CD274 and colonic neoplasm: TAMs also express PD-L1 and this expression negatively correlates with their phagocytic activity, so monoclonal antibodies that block the PD1/PDL1 axis were found to reduce tumor growth in macrophage-dependent fashion using in vitro and in vivo colon cancer models and improve macrophage-mediated T-cell activation in in vivo hepatocellular cancer studies [64,190,191].