VEGFA and neoplasm: In particular, M2 TAMs are involved in immune suppression, tumor migration, invasion, and angiogenesis by releasing vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-7, MMP-9, IL-12, high levels of IL-10, TGF-β, hepatocyte growth factor and basic fibroblast growth factor, adrenomedullin, urokinase-type plasminogen activator, thymidine phosphorylase, prostaglandin E2, and semaphoring 4D [66].