Taking into account these important technical limitations, multiple studies have highlighted the progressive shift from a Th1-enriched TME, as observed in early stage MF skin lesions, towards a Th2-oriented TME in the advanced stages, with the loss of Th1 markers and activated CD8+ cells and increased expression of Th2 markers, such as GATA3, IL-4, IL-5, and IL-13 [56,77,82,94,95,96,97,98]. Here, CD8A is linked to mycosis fungoides.