IGF1 and amyotrophic lateral sclerosis: Immunofluorescence of neurite intensity showed that compared with control (Figure 9(a1)), IGF-1 (Figure 9(a5)) and IWP-2 (Figure 9(a4)) treatments enhanced ALS MN neurite growth, whereas cotreatment with IGF-1 and IWP-2 did not show additional effects compare with individual treatments (Figure 9(a7)).