Interestingly, a recent study demonstrated a similar role for GSK3β in an SOD1E100G iPSC-based ALS model: Bhinge et al. (2017) found that XAV-939 (a tankyrase inhibitor, also as an indirectly GSK3β activator) treatment postponed the death of SOD1E100G MNs [33]. The gene discussed is TNKS; the disease is amyotrophic lateral sclerosis.