NFKB1 and glioblastoma: Furthermore, in certain contexts, NF-κB transcriptional activity protects against apoptosis [14,15,16,17], while inhibition of NF-κB with SN50, or inhibition of mTOR with rapamycin, has been shown to reduce the sphere forming ability of the glioblastoma CSCs and pancreatic CSCs, respectively [18,19].