MAP3K5 and metabolic dysfunction-associated steatohepatitis: In a recent study [54], ASK1 inhibition in vivo and in vitro increased hepatic lipid droplet accumulation and/or liver fibrosis, possibly by blocking autophagy; this finding suggests a protective role for liver-expressed ASK1, since ASK1 knockout (KO) mice develop NASH and fibrosis and show altered autophagy.