RTEL1 and idiopathic pulmonary fibrosis: Genomic analysis has identified several genetic mutations associated with an increased risk of developing IPF, including telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) and the regulator of telomere elongation helicase 1 (RTEL1)—all of which are linked to premature senescence and a reduced regenerative capacity of type II pneumocytes [229].