Six of the 8 patients shared only NON MPN-driver somatic mutations between the two cells’ subpopulations: TET2 and NOTCH1 in one case, and individual paired mutations in TP53, KIT, SRSF2, NOTCH1 and WT1, in the other 5 patients. The gene discussed is NOTCH1; the disease is myeloproliferative neoplasm.