Steroids (e.g., dexamethasone), IL-4, IL-10, secretory leukocyte protease inhibitor (SLPI), prostaglandin E2 (PGE2) and colony-stimulating factor 1 receptor (CSF-1R) agonists have been explored for macrophage reprogramming in liver diseases [220]. This evidence concerns the gene CSF1R and liver disorder.