BDNF and irritable bowel syndrome: Since NTs, known for their involvement in the regeneration and development of SNC, are overexpressed during a pathophysiological alteration in the gut, including Irritable Bowel Disease (IBS) and colitis [36], we investigated the Brain-Derived Nerve growth Factor (BDNF) and Neurotrophin-3 (NT-3) expressions in the intestine following NTG injection in mice.