Thus, considering that the physiological changes highlighted as a deregulated release of neurotransmitters in the ENS and their defective binding to the receptors are evident following migraine, which might be considered as crosstalk between the CNS and mucosal innervation, we demonstrated that the BDNF and NT-3 expression was significantly decreased in SCFA-treated mice, suggesting that SP and SB could accelerate mucosal recovery following intestinal compromise due to the inflammatory process activation in the brain. The gene discussed is NTF3; the disease is migraine disorder.