ACE2 and COVID-19: Another possible reason of the increase in Ang-(1-7) level in COVID-19 is its formation via non-ACE2 pathways, i.e., through the cleavage of AngI via NEP or TO and of AngII via POP, especially since the latter pathway has been suggested as dominant for AngII to Ang-(1-7) conversion in lungs and the circulating system [95].