ATG4B and cancer: Inhibition of ULK1 sensitizes cancer cell to nutrient stress [188] and mTOR inhibitors [189]; inhibition of VSP34 has shown to improve the effect of mTOR inhibition and tyrosine-kinase inhibitor on suppression of cancer growth [190,191]; inhibition of ATG4B, a protease that controls lipidation and delipidation of mATG8s [192], also suppresses cancer progression [193].