Brown et al. [30] also demonstrated how mast cells respond to dengue virus infection by producing type I interferons and chemokines including CCL4, CCL5, and CXCL10, in addition to TNF-α, responsible for inducing endothelial activation and consequent vascular losses, a hallmark of severe Dengue virus infection [31,32]. This evidence concerns the gene CCL5 and dengue disease.