Among hypoxia-responsive genes identified in our in vitro hypoxic system, we also found potential cardiac biomarkers (BIRC5, ENG, HMOX1, VEGF, STC1, STC2, and SERPINE1) which they may have potential clinical value in the diagnosis and prognosis of coronary artery diseases (Figure 4). This evidence concerns the gene HMOX1 and coronary artery disorder.