For instance, Alzheimer ́s disease (AD) is characterized by the deposition of two distinct types of aggregates in the temporal and parietal lobes of the brain: extracellular plaques composed of amyloid-β (Aβ) peptides (cleavage products of the transmembrane protein APP), and intracellular neurofibrillary tangles composed of tau proteins [3]. Here, MAPT is linked to Alzheimer disease.