It has been shown that SIRT6 can affect the IGF-1/Akt signaling pathway, which regulates systemic aging processes and induces hypertrophy of myocardial cells in the myocardium, increasing predisposition to heart failure by deacetylating histone H3K9 in regions of promoters of IGF-1 up-regulating genes. The gene discussed is IGF1; the disease is heart failure.