SIRT3 in AD has been shown to prevent OS induction through deacetylation of SOD2; disruption of mitochondrial membrane potential; and activation of dynamin-related protein 1 (DRP1) and mitochondrial fission 1 protein (FIS1) factors promoting excessive mitochondrial cleavage, leading to neuronal death due to disrupted ability of mitochondria movement to the synapse and disrupted ATP supply [151]. Here, FIS1 is linked to Alzheimer disease.