SREBF1 and obesity due to melanocortin 4 receptor deficiency: High fat diet-induced obesity mice also showed increased levels of SREBP-1c, reduced hepatic levels of SIRT1, increased expression of the lipogenesis genes: SREBP-1c and Fas, and decreased expression of genes associated with fatty acid oxidation: ECI (3,2-trans enoyl-CoA-(∆) isomerase) and MCAD (medium-chain acyl-coenzyme A dehydrogenase) compared to the control group [37].