A limited number of phospho-protein substrates have been identified for CIN, consisting of cofilin [83], phosphorylated steroid receptor coactivators 1 and 3 [84], and neurofibromin 2 (aka merlin), a tumor suppressor protein encoded by the NF2 gene mutated in neurofibromatosis type 2 [85]. The gene discussed is NF2; the disease is NF2-related schwannomatosis.