Additionally, a decline in O-GlcNAcylated proteins occurs in spinal cords of mouse models of Amyotrophic Lateral Sclerosis (ALS) during motor neuron atrophy and in mice deficient in a reactive oxygen species (ROS) sensor (NPGPx), a direct modulator of O-GlcNAcase [140]. Here, GPX7 is linked to amyotrophic lateral sclerosis.