CFL1 and Mental deterioration: The formation of cytoplasmic rod-shaped bundles containing cofilin and actin have been studied in neurons: (1) overexpressing or acutely activating (dephosphorylating) cofilin; (2) exposed to energetic, oxidative or excitotoxic stress including hypoxia/ischemia; and (3) exposed to factors associated with progressive cognitive decline in age-related neurodegenerative diseases.