CFL1 and neoplasm: Interestingly, sirtuin2 (SIRT2), a tumor suppressor and member of the class III histone deacetylase (HDAC) family, suppresses actin polymerization in cancer cells through deacetylation of Hsp90, resulting in increased dephosphorylation of cofilin [97], a process consistent with CIN participation (Figure 5).