PSIP1 and posterior cortical atrophy: Our group demonstrated previously that ectopic overexpression of LEDGF/p75 in PCa cells confers protection to DTX-induced cell death, its endogenous levels of LEDGF/p75 are upregulated in mCRPC cellular models selected for DTX resistance, and targeting this protein in chemoresistant PCa cells can resensitize them to taxanes [6,9].