The upregulation of the LEDGF/p75 IBD interactome in DTX-resistant PCa cells is likely to increase global RNAPII-mediated transcription, consistent with the notion that cancer cells become “addicted” to high levels of transcription to maintain their malignant phenotype, including resistance to stressors such as chemotherapeutic drugs and inhibitors of transcription [59]. Here, ACAD8 is linked to posterior cortical atrophy.