In addition, our group and others demonstrated that LEDGF/p75, also known as the dense fine speckled autoantigen of 70 kD (DFS70) and PC4 and SFRS1-interacting protein (PSIP1), is upregulated in PCa and other cancers and contributes to tumor aggressive properties, including chemoresistance [7,8,9,10,11,12,13,14,15]. The gene discussed is PSIP1; the disease is cancer.