Using co-IP and confocal microscopy approaches, we took advantage of the upregulation of this interactome in DTX-resistant cells, and the availability of highly specific human anti-LEDGF/p75 autoantibodies (known as DFS or anti-DFS70 autoantibodies), to establish that LEDGF/p75 interacts endogenously with its known IBD-binding partners in a pre-clinical cellular model of cancer chemoresistance. Here, PSIP1 is linked to cancer.