Med-1, a mediator of RNAPII transcription and interactor of the bromodomain protein 4 (BRD4), an SE assembly protein, was recently implicated in leukemia chemoresistance via interaction with LEDGF/p75 [15] and in enhancing the stemness and metastasis of squamous cell carcinoma via SE formation [64]. The gene discussed is PSIP1; the disease is squamous cell carcinoma.