IWS1 and posterior cortical atrophy: To evaluate the contribution of the LEDGF/p75 IBD interactome to PCa chemoresistance, we first assessed the endogenous protein expression of LEDGF/p75 and its known IBD-interacting partners JPO2, menin, MLL, IWS1, ASK1, PogZ, and Med-1 in AR-independent DTX-resistant PC3-DR and DU145-DR cell lines compared to their drug-sensitive, parental counterparts.