PCa resistance to taxanes involves the interplay between multiple molecular mechanisms, including increased activation of anti-apoptotic proteins, multi-drug resistant transporters, cytokines and chemokines, stress and antioxidant proteins, AR variants, GR signaling, microtubule alterations, miRNAs, and EMT/CSC-associated signaling pathways [3,4,6,47,48,49]. Here, NR3C1 is linked to posterior cortical atrophy.