Previously, we reported that the transition of chemosensitive mCRPC cells to taxane resistance is characterized by the activation of a transcriptomic program associated with increased epithelial-to-mesenchymal transition (EMT) and stemness, and upregulation of cancer cell survival proteins, such as lens epithelium-derived growth factor of 75 kD (LEDGF/p75) and c-MYC [6]. The gene discussed is MYC; the disease is cancer.