The upregulation of the LEDGF/p75 IBD interactome in DTX-resistant PCa cells and its impact on cell survival led us to investigate the effects of individual silencing of LEDGF/p75, JPO2, and menin on the clonogenicity and tumorsphere formation capacity of PC3-DR and DU145-DR cells. This evidence concerns the gene PSIP1 and posterior cortical atrophy.