Although drug resistance mechanisms may differ from one cancer type to another, the recent report that LEDGF/p75-induced chemoresistance in mixed-lineage leukemia cells involves the activation of cell cycle genes, regulation of the expression of BRD4 and Med-1, and activation of nuclear SE [15] raises the question of whether LEDGF/p75 and its IBD-interacting partners, and possibly PWWP-interacting proteins, induce taxane resistance in PCa cells via similar mechanisms. The gene discussed is MED1; the disease is cancer.