CCN2 and neoplasm: Example I-12 (Isomer 2) administered at 10 mg/kg PO in BALB/c mice shows Cmax = 23 ng/mL and AUC0-last = 48 ng·h/mL, as well as > 50% downregulation of tumor CTGF mRNA upon 3 days of treatment at 50 mg/kg IP of mice bearing NCI-H226 tumors.