Example I-186 (Isomer 1) administered at 10 mg/kg PO in BALB/c mice shows Cmax = 110 ng/mL and AUC0-last = 435 ng·h/mL, as well as >50% downregulation of tumor CTGF mRNA upon 3 days of treatment at 30 mg/kg PO of mice bearing NCI-H226 tumors. This evidence concerns the gene CCN2 and neoplasm.