Dose-dependent PPI disruption H226 of the YAP1–TEAD1/4 PPI and TAZ–TEAD1/4 by Co-IP in H226K-975 inhibited cell proliferation more potently in NF2-non-expressing cell lines as part of a 14 cell line mesothelioma panel. The gene discussed is YAP1; the disease is mesothelioma.