Thus, Yap1 gene amplification appears to occur in mice under KRAS ablation in a KRAS G12D-dependent mouse pancreatic tumor model [7], while a genome-scale cDNA screen identified activation of YAP1 as a factor for survival upon KRAS knockdown in KRAS G13D mutant colorectal cancer cell lines [43]. The gene discussed is KRAS; the disease is colorectal cancer.