COPS8 and colorectal cancer: In addition, recent studies indicate constitutively photomorphogenic 9 signalosome subunit 8 (CSN8) can stabilize HIF-1α protein through deubiquitylation and upregulates HIF-1α transcription in a nuclear factor-κB (NF-κB)-dependent manner in the hypoxia tumor microenvironment, leading to epithelial–mesenchymal transition (EMT) and dormancy of colorectal cancer cells [58].