Cancer cells rely on oxidative stress to promote proliferation and progression; however, under excess oxidative conditions (for instance, chemotherapy, radiotherapy), ROS may inactivate integrins and activate TGF-β2 on the membrane of some tumor cells, leading to the activation of p38 and downstream signaling (for example, ER-stress signaling), which ultimately causes cancer cell dormancy. The gene discussed is TGFB2; the disease is neoplasm.