THBS1 and cancer: Recent studies indicate that the induction of a microenvironment by nasal instillation of lipopolysaccharide (LPS) or tobacco smoke exposure causes the formation of neutrophil extracellular traps (NETs), leading to the proteolysis of the extracellular matrix (ECM) protein laminin and thrombospondin-1 (TSP-1) degradation, which mediates dormant cancer cells reactivation through integrin-dependent pathways [6,123].