EIF2AK3 and cancer: Redox-mediated activation of IRE1α and ATF6α may support dormant cancer cell survival, while activating PERK phosphorylates eukaryotic initiation factor 2α (eIF2α) and inhibiting its translation of cyclin-dependent kinases (CDK4), Cyclin D1/D3, leading to quiescence of dormant cancer cells [47].