In line with our previous findings [10], in this new reanalysis, NPC2 showed the highest AUROC values for TB vs. non-TB discrimination among Brazilians (AUROC, TB vs. control/LTBI: 0.94), which was validated in the Indian (TB vs. LTBI: 0.98) as well as the British (TB vs. control: 0.99) cohort. Here, NPC2 is linked to tuberculosis.