CFLAR and pancreatic ductal adenocarcinoma: Interestingly, c-FLIP+CD14+ monocytes isolated from patients with pancreatic ductal adenocarcinoma (PDAC) expressed high levels of CD38 and programmed death-ligand 1 (PD-L1), and an increase in c-FLIP+PD-L1+CD14+ cell number in combination with high levels of serum IL-6 has been identified as a negative independent prognostic factor for both overall survival and disease free survival (DFS) [65].