Even if Dab2 upregulation is mediated by M-CSF, it is not sufficient for full gene induction based on the observations that physical interactions between myeloid cells and extracellular matrix proteins are essential to guide the acquisition of a functional pro-tumour phenotype, thus highlighting the crucial impact of matrix stiffness on driving macrophage polarisation by YAP/TAZ signalling [95]. The gene discussed is CSF1; the disease is neoplasm.