CD8A and neoplasm: α-difluoromethylornithine (DFMO), an irreversible inhibitor of ODC activity that is currently used in clinics for its anti-carcinogenesis activity, was demonstrated in combination with the Trimer polyamine transport inhibitor to significantly reduce tumour growth in comparison to that observed in response to treatments alone by decreasing the number of tumour-infiltrating MDSCs and by improving CD8+ T cell activation in two different tumour mouse models [231].