NFKB1 and neoplasm: However, PGE2 could even be considered as an epigenetic ‘hacker’ of M-MDSCs functions, as it drives the accumulation of nuclear NF-κB p50 protein in M-MDSCs purified from the spleens or BM of fibrosarcoma-tumour-bearing mice and also from human circulating M-MDSCs isolated from patients with colorectal cancer [87].