As tumour-reprogrammed M-MDSCs displayed a significantly increased expression of both mTOR and glycolysis-associated genes, including Glut1, Hk2, Gpi, Tpi, Eno1, Pkm2, Ldha, and MCT4, mTOR targeting by rapamycin not only decreased glycolysis but also inhibited the expression of immunosuppression-associated targets such as ARG1 and PD-L1. This evidence concerns the gene SLC2A1 and neoplasm.