Treatment with luseogliflozin and canagliflozin reduced aortic gene expression of adhesion molecules, metalloproteinases MMP-2 and MMP-9, the inflammatory cytokines TNF-α and IL-1 and 6, and MCP-1 in ApoE−/− mice with induced diabetes, to levels comparable to non-diabetic ApoE−/− mice [45,51], as well as reducing plaque burden in diabetic Apo E−/− mice compared to controls [45]. This evidence concerns the gene APOE and diabetes mellitus.