NPRL2 and non-small cell lung carcinoma: Study of the role of NPRL2 in DNA damage response in non-small-cell-lung cancer cells treated with cisplatin [160] demonstrated that the ectopic expression of NPRL2 activates the DNA damage checkpoint pathway in cisplatin-resistant and NPRL2-negative cells, leading to cell cycle arrest in the G2/M phase and induction of apoptosis.