Hemizygous microdeletions in the 22q11.2 region, CNVs which include the DGCR8 gene, lead to an ~20- to 25-fold increase in SCZ risk [37,38], and studies in animal models of 22q11.2 deletion syndrome (22q11DS) report widespread deficits in brain miRNA levels [39,40]. The gene discussed is DGCR8; the disease is 22q11.2 deletion syndrome.