Our lab has found that Dgcr8 haploinsufficiency underlies two age-dependent deficits in 22q11DS mouse models that may be related to auditory hallucinations in patients: behavioral deficits in PPI in an acoustic startle reflex and synaptic deficits in thalamocortical excitatory projections from the medial geniculate nucleus (i.e., auditory thalamus) to the primary auditory cortex [271]. The gene discussed is DGCR8; the disease is 22q11.2 deletion syndrome.