This suggests that BD exhibits a pattern to prevent cancer progression by up-regulating the protective genes (NFKBIE, LIFR, SERPINB9, etc.), which were down-regulated due to acidification, rather than down-regulating the risk genes (FAM114A1, PLAC8, SCUBE2, etc.), which were up-regulated due to acidification. The gene discussed is SERPINB9; the disease is cancer.