As a result, the ER+ cancer sample was clustered with ER+ tumor cells (ESR1+, KRT18+, and KRT5−), KRT5+/EPCAM+ double-positive cells, cancer-associated fibroblasts (CAFs) (DCN+), macrophages (CD68+), KRT5+/EPCAM− cells, and endothelial cells (VWF+) (Figure 5A,B). The gene discussed is ESR1; the disease is cancer.