The frequency of CD4+ T cells expressing stimulatory checkpoint molecule 4-1BB and OX40 was significantly higher in AIH untreated group compared to Normal group (4-1BB+ CD4+ T cells: 5.2 ± 0.7% vs. 1.4 ± 0.6%, p = 0.0010, OX40+ CD4+ T cells: 6.6 ± 0.9% vs. 3.4 ± 1.4%, p = 0.0443), while the inhibitory immune checkpoint molecules were similarly expressed by CD4+ T cells from different groups. The gene discussed is CD4; the disease is autoimmune hepatitis.