The IKK/NF-κB signaling system is already active during neuroectodermal development [7], is present in the different cell types of the adult nervous system [8] and its activation in astrocytes and microglia, for example, Aβ-mediated toll-like receptor signaling is a critical step in the initiation of neuroinflammation in AD [9,10]. The gene discussed is NFKB1; the disease is Alzheimer disease.