IKBKB and amyotrophic lateral sclerosis: Notably, in our previous study [25], using GFAP/IKK2-CA mice in the context of ALS, we proposed WNT family members as paracrine effectors to be involved in the expansion of microglia in the spinal cord, and the administration of the Porcupine WNT acyltransferase inhibitor C59 indeed decreased microglia density.