Jae-Young Cho et al. [13] further found that eNOS, 3-NT, and GFAP colocalized in the brain of AD mice model, and that the change pattern was similar to that of GFAP, suggesting that the ability of FA to protect the brain from Aβ-induced toxicity may be mediated by inhibiting the expression of eNOS and 3-NT in astrocytes. This evidence concerns the gene GFAP and Alzheimer disease.