NDRG2 was shown to suppress the TGF-β1-mediated induction of MMP through the regulation of integrin α3 expression in hepatocarcinoma and integrin α6 expression in metastatic murine breast cancer cells (4T1), thereby suppressing the activation of latent extracellular TGF-β [17,26]. The gene discussed is TGFB1; the disease is breast carcinoma.