GDF2 and diabetic cardiomyopathy: Our results showed BMP-7 enhances EPCs and neovascularization in diabetic cardiomyopathy, this observation was in agreement with other unrelated studies using rhBMP-7 or stem cell overexpressing BMP7- in repairing the nonunion fracture [51,52], or with other types of BMP effects as BMP-9 to improve neovascularization of hind limb ischemia [53].