Here, we report inflammation-induced cell death mediated by inflammatory cells (macrophage and dendritic cells) and inflammasome formation (TLR4, NLRP3) and NLRP3 activators (Nek7 and GBP5) that cause cardiac cell death is the key player in the development and progression of diabetic cardiomyopathy. Here, TLR4 is linked to diabetic cardiomyopathy.