GPBAR1 and metabolic dysfunction-associated steatohepatitis: Shi et al. showed that in both humans and mice with NASH, hepatic GPBAR1 expression was reduced and GPBAR1-deficient mice exhibited exacerbated liver damage, increased levels of proinflammatory cytokines and facilitated macrophage polarization by promoting NACHT, LRR and PYD domain-containing protein 3 (NLRP3) inflammasome activation [79].