SPRY2 and colorectal carcinoma: In parallel with tumors and adjacent normal colon samples, 3 CRC cell lines: RKO, Caco2, and HCT116 cells, 3 non-transformed cell lines: FHs74, and CCD-841 colonocytes and CCD-18Co colonic fibroblasts were assayed using COBRA in the same 4 regions of SPRY2 as previously explored in primary malignant colonocytes and adjacent control colonocytes.