SPRY2 and adenocarcinoma: According to the DNA Methylation Interactive Visualization Database (DNMIVD), SPRY2 promoter methylation is decreased in adenocarcinomas compared to control mucosa (Figure 2a), which complements the inverse correlation found between SPRY2 methylation and mRNA expression in adenocarcinomas archived in cBioPortal’s database (Figure 2b) [37,38].