SPRY2 and colorectal carcinoma: While Feng et al. reported an inverse relationship between SPRY2 (down) and miR-21 (up) gene expression in later stages of CRC, increases in SPRY2 promoter 5mC levels as shown in HCT116 cells and potentially some CRCs could be a consequence of miR-21 signals or could be up-stream of miR-21 gene activation or perhaps an unrelated and indirect consequence.