However, when scanning 450K methylation probe data in regions #2 and #3 from TCGA (unpublished observation), we find subtle decreases in 5mC levels of dinucleotide CG#11207507 within a few base pairs of the transcriptional start site (TSS) of SPRY2 that were associated with increased tumor sizes in CRC. The gene discussed is SPRY2; the disease is neoplasm.