A study on primary mouse astrocyte cultures and on HEK293T cells has shown that inducing a loss of function of Kir4.1, by either antidepressant drugs (fluoxetine, sertraline, fluvoxamine, imipramine, and mianserin) or RNA silencing (siRNA), results in a significant increase in mRNA and protein levels of BDNF [53], a modulator of both depression [21,70] and epileptogenesis [71,72]. This evidence concerns the gene BDNF and major depressive disorder.