Interestingly, several antidepressant drugs have been shown to affect Kir4.1 function or trafficking [44,45,46], and an altered expression of the Kir4.1 channel in different brain areas has been associated with depression-like behaviors in rodents [37,47] and observed in brain from patients with depression in post-mortem studies [38,39]. The gene discussed is KCNJ10; the disease is major depressive disorder.