To deal with this aspect of the Kir4.1 metabolism, we can hypothesize the presence of conditions seen already in other Kir4.1-related conditions such as epilepsy, which is often seen in comorbidity with depression [93], where it has been documented either loss [94,95] or gain [96] of function KCNJ10 variants. The gene discussed is KCNJ10; the disease is epilepsy.