In contrast to previous studies, one work [55] performed on CSDS (susceptible mice after chronic social defeat stress), a model of depression based on the stress paradigm [64], found no change in Kir4.1 expression in the prefrontal cortex [65,66], nucleus accumbens [67,68] and hippocampus [69] and concluded that Kir4.1 is not essential in the CSDS model of depression. This evidence concerns the gene KCNJ10 and depressive disorder.