Among the large number of astrocyte proteins acting at the tripartite synapse, recent evidence has focused on the inward rectifier potassium channel 4.1 (Kir4.1 channel; KCNJ10 gene) as a possible contributor to several neuropsychiatric diseases [36], including depression [37,38,39,40,41]. This evidence concerns the gene KCNJ10 and major depressive disorder.