The first association of astrocytic Kir4.1 channels with depression emerged from the evidence that several antidepressant drugs, in particular TCAs and SSRIs, are able to inhibit currents through the channel [44,45] by direct interaction [52], suggesting that Kir4.1 inhibition could have an antidepressant action [40]. Here, KCNJ10 is linked to major depressive disorder.