HSP70 and client peptide HINT1 (histidine triad nucleotide-binding protein-1, a protein having an active role in the p53 signaling pathway [52]) mediate immunoregulation through CD94 and NKG2D (NKG2-D type-II integral membrane protein; a costimulatory receptor of NK-cells [72]) signaling in a mouse model of experimental autoimmune encephalomyelitis (EAE) [73]. Here, KLRK1 is linked to experimental autoimmune encephalomyelitis.