EGFR and non-small cell lung carcinoma: First-generation EGFR-TKIs (gefitinib, erlotinib, and icotinib) and second-generation EGFR-TKIs (afatinib and dacomitinib) have poor BBB permeability and provide a higher ORR of approximately 60% of intracranial lesions in NSCLC CNS metastasis compared with that of WBRT with or without chemotherapy (ORR < 40%) [60,61,62,63,64].