NLRP3 and keratoconus: Bile acid dependent mechanisms are still not fully understood as current studies are limited to experiments in hepatic cell lines, primary hepatocytes, cholangiocytes, peritoneal macrophages and bone marrow-derived macrophages (BMDMs) [15,23,25,26]; although, the NLRP3 inflammasome was shown to be functional in KC and HSC as well [27].