In 2009, Qu et al. [78] reported that gastric cell line (SGC7901)-derived exosomes could promote the proliferation of gastric cancer cell lines (SGC7901 and BGC823) through the MAPK and PI3K/Akt/mTOR pathways, providing evidence that cancer-derived exosomes can regulate cancer growth. This evidence concerns the gene AKT1 and gastric cancer.