PTEN and esophageal adenocarcinoma: This is because esophageal adenocarcinoma-derived exosomes and microvesicles could promote the post-transcriptional downregulation of the phosphatase and tensin homolog (PTEN) and the apoptosis-inducing factor 2 (AIFM2) gene in a miR-25- and miR-210-dependent manner [80].