However, under pathological conditions with endothelial dysfunction and endothelial nitric oxide synthase (eNOS) uncoupling, e.g., preeclampsia and atherosclerosis, the endothelial bradykinin B2 receptor stimulates the generation of reactive oxygen species and thereby loses its cardioprotective functions [80,81,82]. The gene discussed is BDKRB2; the disease is endothelial dysfunction.