Third, shielding of the DRY motif of B2R by site-directed antibodies against the connecting loop between membrane domains III-IV of B2R prevented the angiotensin II-stimulated Gαq/11 (Gq/11 protein alpha subunit) activation and redistribution on maternal vessels of pregnancies complicated with preeclampsia [12]. Here, BDKRB2 is linked to preeclampsia.